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Regulatory role of microRNAs on PTEN signaling

Soudeh Ghafouri-Fard1, Atefe Abak2, Hamed Shoorei3

  • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|November 9, 2020
PubMed

Insights

MicroRNAs (miRNAs) regulate the tumor suppressor Phosphatase and tensin homolog (PTEN) gene. Understanding these miRNA-PTEN interactions is crucial for cancer prevention and treatment, and managing other diseases.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The Phosphatase and tensin homolog (PTEN) gene is a critical tumor suppressor.
  • PTEN negatively regulates the PI3K/AKT signaling pathway, impacting cell growth and survival.
  • Dysregulation of PTEN is implicated in various malignancies and non-malignant disorders.

Purpose of the Study:

  • To review the regulatory roles of microRNAs (miRNAs) in PTEN expression and activity.
  • To highlight the significance of understanding miRNA-PTEN interactions in cancer and other diseases.

Main Methods:

  • Literature review of studies investigating miRNA-PTEN interactions.
  • Analysis of the functional consequences of these interactions in different biological contexts.

Main Results:

  • Numerous miRNAs have been identified to directly interact with and inhibit PTEN expression.
  • Suppression of PTEN by miRNAs can affect cancer cell response to chemotherapy.
  • miRNA-PTEN interactions are also relevant in non-malignant conditions like myocardial infarction and stroke.

Conclusions:

  • miRNAs are significant regulators of PTEN, influencing both its expression and activity.
  • Targeting miRNA-PTEN interactions may offer therapeutic strategies for cancer and other diseases.
  • Further research into these interactions is essential for clinical applications.
Keywords:
CancerDisorderPTENmiRNA

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