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A highly selective and simple fluorescent probe for salbutamol detection based on thioglycolic acid-capped CdTe
Jinyan Zhang1, Yihua Wei1, Suyan Qiu1
1Institute for Quality & Safety and Standards of Agricultural Products Research, Jiangxi Academy of Agricultural Sciences, Nanchang 330200, PR China; Laboratory of Quality Institute & Safety Risk Assessment for Livestock and Poultry Products (Nanchang, Ministry of Agriculture and Rural Affairs), Nanchang 330200, PR China.
Abstract:
In this paper, a highly fluorescent water-soluble CdTe quantum dots (CdTe QDs) stabilized with thioglycolic acid (TGA) were synthesized for the quantitative and selective determination of salbutamol (SAL). When ten different of 2.09 × 10-6 mol L-1 alpha-2 adrenoceptor agonist were added to 4.38 × 10-4 mol L-1CdTe QDs solution, the fluorescence signal of the CdTe QDs quenched obviously by SAL with 57.32% and 0.815% - 7.00% for other nine kinds of veterinary medicine, such as tulobuterol, fenoterol, phenylethanamine A, simatero, penbutolol, clenbuterol, ractopamine, terbutaline and clorprenaline. The result shows that the CdTe QDs is highly sensitive sensor for SAL. The quenching mechanism has been investigated by absorption spectroscopy and KSV at different temperatures, and shew a static quenching process than dynamic quenching. Under the optimal conditions, respectively the straight line equation (F0/F = 0.1491 × 106 C + 1.3078) was found between the relative fluorescence intensity and the concentration of SAL was in the range of 6.27 × 10-8 to 2.09 × 10-7 mol L-1, and the limit of detection was 4.2 × 10-8 mol L-1. The proposed method has been applied to the determination of SAL in pig urine samples.
