Endotoxemia coupled with heightened inflammation predicts future depressive symptoms
Annelise A Madison1, Rebecca Andridge2, Avelina C Padin1
1Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, United States; Department of Psychology, The Ohio State University, United States.
Psychoneuroendocrinology
|November 9, 2020
Summary
Elevated endotoxemia markers, like lipopolysaccharide-binding protein (LBP), predict future depressive symptoms, especially when combined with inflammation. Gut barrier dysfunction may contribute to depression risk.
Area of Science:
- Neuroscience
- Immunology
- Gastroenterology
Background:
- Gut barrier abnormalities and endotoxemia are linked to depression.
- This study investigates the longitudinal relationship between endotoxemia and depressive symptoms.
Purpose of the Study:
- To examine longitudinal associations between endotoxemia markers and depressive symptoms.
- To explore the role of inflammation in this relationship.
Main Methods:
- 315 women (cancer survivors and controls) provided blood samples and completed depression questionnaires over three annual visits.
- Assessed inflammatory markers (IL-6, TNF-α, CRP) and endotoxemia markers (LBP, sCD14, LBP/sCD14 ratio).
Main Results:
- Higher baseline lipopolysaccharide-binding protein (LBP) and LBP/soluble CD14 (sCD14) ratio predicted increased depressive symptoms at follow-up visits.
- A significant interaction indicated endotoxemia fueled depression only with elevated inflammation.
- Depressive symptoms did not predict future endotoxemia.
Conclusions:
- Endotoxemia, particularly with systemic inflammation, may drive depressive symptoms.
- Bacterial endotoxin translocation from the gut could be implicated in depression.
- Interventions targeting endotoxemia and inflammation may reduce depression risk.
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