Growth Faltering: Underweight and Stunting

Andrew M Prentice1

  • 1MRC Unit The Gambia at London School of Hygiene and Tropical Medicine, Banjul, Gambia, aprentice@mrc.gm.

Insights

Growth faltering in young children, often overlooked after the first 1,000 days, can be reversed. This study explores recovery possibilities and optimal nutrition for toddlers and preschoolers.

Area of Science:

  • Pediatrics
  • Human Nutrition
  • Developmental Biology

Background:

  • Most research on growth faltering focuses on the first 1,000 days of life.
  • There's a common belief that stunting and wasting in early childhood are irreversible.
  • This paper examines critical periods of growth faltering and recovery potential.

Purpose of the Study:

  • To describe the timing of stunting and wasting development.
  • To investigate the possibility of recovery from growth faltering in toddlers and preschoolers.
  • To discuss nutritional strategies for young children.

Main Methods:

  • Review of existing literature on growth faltering.
  • Analysis of hormonal mechanisms regulating early growth.
  • Examination of recovery data in toddlers and preschoolers.

Main Results:

  • Growth faltering can occur during intergenerational, in utero, and early postnatal periods.
  • Evidence suggests that recovery from stunting and wasting is possible in toddlers and preschoolers.
  • Hormonal factors play a significant role in early growth regulation.

Conclusions:

  • Catch-up growth is achievable in later early childhood, challenging previous assumptions.
  • Targeted nutritional interventions may be beneficial for toddlers and preschoolers.
  • Further research into the hormonal regulation of growth is warranted.

Related Concept Videos

Nature and Nurture01:10

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
21.8K
Anorexia Nervosa01:28

Anorexia Nervosa

Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
576
Overview of Protein Metabolism01:21

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
3.1K
Signs of Puberty01:27

Signs of Puberty

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
1.0K
Metabolic States of the Body: Fasting and Starvation01:24

Metabolic States of the Body: Fasting and Starvation

During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
2.3K
Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
956