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Antibody-Based Immunotherapeutic Strategies for COVID-19

Jamal Hussen1, Mahmoud Kandeel2,3, Maged Gomaa Hemida1,4

  • 1Department of Microbiology, College of Veterinary Medicine, King Faisal University, Al-Ahsa 31982, Saudi Arabia.

Pathogens (Basel, Switzerland)
|November 10, 2020
PubMed

Insights

Antibody-based immunotherapeutics, including neutralizing antibodies and monoclonal antibodies, show promise for preventing and treating COVID-19. Clinical trials are evaluating their effectiveness and potential drawbacks for managing SARS-CoV-2 infections.

Area of Science:

  • Immunology
  • Virology
  • Clinical Medicine

Background:

  • Global containment of COVID-19 relies on vaccines and therapeutics.
  • Passive antibody therapies, including convalescent plasma and monoclonal antibodies (MAbs), are key strategies.
  • Immunomodulatory antibodies are being investigated to enhance host defense and mitigate immune overreactions.

Purpose of the Study:

  • To provide an updated overview of clinical trials for SARS-CoV-2 antibody-based immunotherapeutics.
  • To highlight the progress and challenges of these treatments.
  • To analyze the pros and cons of antibody-based strategies against SARS-CoV-2.

Main Methods:

  • Review of clinical trials registered at ClinicalTrials.gov.
  • Analysis of data on SARS-CoV-2-specific neutralizing antibodies (NAbs) and MAbs.
  • Evaluation of immunomodulatory antibody mechanisms and clinical trial outcomes.

Main Results:

  • Several antibody-based therapies are in various stages of clinical trials.
  • NAbs and MAbs demonstrate potential for both prophylaxis and treatment of COVID-19.
  • Immunomodulatory antibodies aim to balance immune response for better patient outcomes.

Conclusions:

  • Antibody-based immunotherapeutics represent a significant area of research for COVID-19.
  • Ongoing clinical trials are crucial for determining the efficacy and safety of these treatments.
  • Understanding the benefits and limitations of these therapies is essential for clinical application.
Keywords:
COVID-19SARS CoV-2antibodiesclinical trialsimmunotherapy

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