Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

700
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
700
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

3.6K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
3.6K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

617
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
617
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

335
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
335
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

146
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
146
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

9.2K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
9.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Intramuscular Fat Infiltration With Incident Venous Thromboembolism: A Population-Based Cohort Study.

Journal of cachexia, sarcopenia and muscle·2026
Same author

Author Correction: Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis.

Nature communications·2026
Same author

Eu<sup>3+</sup>-mediated ratiometric fluorescence visualization sensing for traceability and content prediction of plant-derived products: an example of Chrysanthemi Flos.

Talanta·2026
Same author

The gut-joint axis in osteoarthritis.

Nature reviews. Rheumatology·2026
Same author

Glucagon-like peptide-1: a critical link between gut microbiota dysbiosis and degenerative musculoskeletal diseases.

Gut microbes·2026
Same author

The application of large language models in orthopedic postgraduate education: potentials, challenges, and future prospects.

Journal of orthopaedic surgery and research·2026

Related Experiment Video

Updated: Dec 1, 2025

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
10:52

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex

Published on: July 27, 2022

3.1K

Rhein Derivatives, A Promising Pivot?

Rui Pei1, Yueping Jiang1, Guanghua Lei2

  • 1Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China.

Mini Reviews in Medicinal Chemistry
|November 10, 2020
PubMed
Summary

Rhein, a natural compound, shows promise for treating diseases like diabetic nephropathy, arthritis, and cancer. Patent analysis reveals its derivatives have significant therapeutic potential, warranting further research.

Keywords:
anthraquinone derivativedrug developmentpatentpharmacological activityrheintherapeutic application

More Related Videos

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
10:12

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols

Published on: April 4, 2014

13.3K
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

25.8K

Related Experiment Videos

Last Updated: Dec 1, 2025

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
10:52

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex

Published on: July 27, 2022

3.1K
Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
10:12

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols

Published on: April 4, 2014

13.3K
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

25.8K

Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Intellectual Property Law

Background:

  • Rhein, an anthraquinone derivative, is recognized for its therapeutic applications.
  • It is particularly noted for treating intractable diseases such as diabetic nephropathy, arthritis, and cancer.
  • Structural modifications of rhein have been a focus in recent decades.

Purpose of the Study:

  • To review patents concerning the pharmacological activity and therapeutic applications of rhein and its derivatives.
  • To analyze patent trends and identify valuable intellectual property in rhein research.
  • To interpret the legal status of key patents related to rhein and its derivatives.

Main Methods:

  • Comprehensive patent literature search from 1978 to 2018.
  • Analysis of patent data focusing on pharmacological activity and therapeutic uses.
  • Identification and presentation of the top 10 most valuable patents.
  • Legal status interpretation of selected patents.

Main Results:

  • The review covers a 40-year period of patent activity for rhein and its derivatives.
  • Key patents demonstrating significant pharmacological activity and therapeutic applications were identified.
  • An interpretation of the legal landscape surrounding rhein-related patents was provided.

Conclusions:

  • Rhein and its derivatives possess superior pharmacological activity.
  • Favorable properties including rich resources, low cost, and low toxicity support further investigation.
  • In-depth research into rhein derivatives is recommended due to their therapeutic potential and economic viability.