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SH3GL3 functions as a potent tumor suppressor in lung cancer in a SH3 domain dependent manner

Zhongkun Lin1, Zhiping Liu1, Xiansheng Tan2

  • 1Department of Oncology, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, #11 Wuyingshan Middile Road, Jinan, Shandong, 250031, China.

Biochemical and Biophysical Research Communications
|November 10, 2020
PubMed

Insights

SH3GL3 acts as a tumor suppressor in lung cancer, inhibiting cancer cell proliferation and survival. Low SH3GL3 expression correlates with poor patient outcomes, suggesting its potential as a diagnostic and prognostic biomarker.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Lung cancer is a leading cause of cancer deaths globally.
  • The role of SH3 domain containing 3 like 3 (SH3GL3) in lung cancer remains largely uncharacterized.
  • Limited prospective studies exist on SH3GL3's function in cancer progression.

Purpose of the Study:

  • To investigate the biological functions of SH3GL3 in lung cancer initiation and progression.
  • To determine the correlation between SH3GL3 expression and patient survival.
  • To elucidate the molecular mechanisms by which SH3GL3 affects lung cancer malignancy.

Main Methods:

  • Analysis of SH3GL3 mRNA and protein levels in lung cancer tissues and cell lines.
  • Overexpression studies to assess the impact of SH3GL3 on cancer cell proliferation, migration, and cell cycle.
  • Investigation of SH3GL3's effect on apoptosis and cancer stem cell self-renewal.
  • Examination of SH3GL3's regulatory role on p21 expression at the transcriptional level.

Main Results:

  • SH3GL3 expression is significantly reduced in lung cancer tissues and cell lines.
  • Lower SH3GL3 levels correlate with decreased survival rates in lung cancer patients.
  • Overexpression of SH3GL3 inhibits lung cancer cell proliferation, migration, and self-renewal of cancer stem cells.
  • SH3GL3 induces cell cycle arrest at the G0/G1 phase and promotes apoptosis.
  • SH3GL3 suppresses lung cancer progression partly by up-regulating p21 transcriptionally.

Conclusions:

  • SH3GL3 functions as a potent tumor suppressor in lung cancer.
  • SH3GL3 inhibits key malignant behaviors of lung cancer cells.
  • SH3GL3's tumor-suppressive activity is partly mediated through p21.
  • SH3GL3 holds potential as a diagnostic and prognostic biomarker for lung cancer.
Keywords:
BiomarkerCell cycleLung cancerLung cancer stem cellSH3GL3p21

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