Related Experiment Video
Updated: Dec 1, 2025
07:27
Olfactory Assays for Mouse Models of Neurodegenerative Disease
Published on: August 25, 2014
22.4K
Olfactory dysfunction in essential tremor versus tremor dominant Parkinson disease
Mahmoud Ebrahim Mostafa Elhassanien1, Wafik Said Bahnasy1, Yasser Abo Elfotoh El-Heneedy1
1Faculty of Medicine, Tanta University, Egypt.
Clinical Neurology and Neurosurgery
|November 10, 2020
Summary
Olfactory testing can help differentiate Essential Tremor (ET) from Tremor-Dominant Parkinson
Area of Science:
- Neurology
- Geriatrics
- Biomarkers
Background:
- Essential Tremor (ET) and Tremor-Dominant Parkinson's Disease (TDPD) are leading causes of geriatric tremor.
- Distinguishing between ET and TDPD can be challenging in clinical practice.
Purpose of the Study:
- To investigate olfactory performance as a potential biomarker for differentiating ET and TDPD.
- To assess the utility of olfactory bulb volumetry (OBV) alongside olfactory testing.
Main Methods:
- 36 ET patients, 22 TDPD patients, and 24 healthy controls (HCS) participated.
- Participants underwent the Sniffin' Sticks Test (SST) for olfactory function and olfactory bulb volumetry (OBV).
Main Results:
- TDPD patients showed significant deficits in SST threshold, discrimination, and identification compared to ET and HCS.
- ET patients also exhibited significant olfactory deficits compared to HCS.
- TDPD patients had significantly reduced OBV compared to ET and HCS.
- A TDI score of 25 demonstrated 94% sensitivity and 91% specificity in differentiating TDPD from ET.
Conclusions:
- Olfactory assessment provides a rapid, safe, and easily applicable method for differentiating TDPD from ET.
- Olfactory testing can serve as a valuable biomarker in cases where ET and TDPD diagnosis is uncertain.
Keywords:
Essential tremorsOlfactory bulb volumetrySniffin’ sticks testTremor dominant Parkinson diseaseMore Related Videos
07:26Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
Published on: September 26, 2019
8.1K
05:54MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
Published on: December 13, 2017
14.5K
Related Concept Videos
01:24Parkinson's Disease: Treatment
785
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
785
01:15Parkinson's Disease: Overview
1.3K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.3K
01:03Olfactory Receptors: Location and Structure
10.7K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
10.7K
01:25Olfaction
47.4K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
47.4K
01:37Neural Regulation
42.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
42.4K
01:20Physiology of Smell and Olfactory Pathway
11.3K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
11.3K