Developmental Results of a Vaccine against Salmonella-Induced Equine Abortion

An inactivated vaccine based on the Sal. abortus equi BN-12 strain with the Bac. subtilis TNP-3 strain filtrate used as immunomodulator has been developed in order to prevent salmonella-induced equine abortion. Preclinical and clinical trials with the white mice and the horses, respectively, are carried out. The lack of toxicity is proven. The vaccine immunogenicity for mouse and mare models comprised 90 and 100%, respectively. The industrial vaccine tests showed that the industrial output of foals increased by 13.8% after immunization. Cost-effectiveness of the vaccine used with the Bac. subtilis TNP-3 strain filtrate comprised 14.1 rubles per 1 ruble of costs, which was 1.8-fold greater when compared to the vaccine used with a polyribonate medicine. It is ascertained that administration of the inactivated vaccine with the Bac. subtilis TNP-3 strain is an effective method to prevent infectious abortion. Scientific and technical documentation is developed based on the survey results in order to submit it for approval to the Rosselkhoznadzor Federal Service for Veterinary and Phytosanitary Surveillance. The instruction is compliant with the approved use. The registration certificate (71-1-10.19-4495 no. PVR-1-1-.6/01631, as of June 10, 2019) has been issued.