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Factors associated with increased mortality in hospitalized COVID-19 patients

Chirag Shah1, Donna J Grando1, Rebecca A Rainess1

  • 1Community Medical Center, 99NJ-37, Toms River, NJ, 08755, USA.

Annals of Medicine and Surgery (2012)
|November 10, 2020
PubMed

Insights

Older age, male sex, and specific health conditions like cardiomyopathy and acute kidney injury are key risk factors for COVID-19 mortality. Identifying these COVID-19 patient characteristics can improve patient outcomes.

Area of Science:

  • Medical Research
  • Epidemiology
  • Public Health

Background:

  • The COVID-19 pandemic has caused significant global health challenges.
  • Limited evidence exists on risk factors predicting COVID-19 patient outcomes.
  • This study aimed to identify key predictors of mortality in COVID-19 patients.

Purpose of the Study:

  • To identify demographic and clinical risk factors associated with increased mortality in COVID-19 patients.
  • To provide data that can guide clinical management and improve patient survival rates.

Main Methods:

  • Retrospective review of electronic medical records for 487 COVID-19 patients.
  • Extraction and analysis of patient variables including demographics, lab results, and pre-existing conditions.
  • Multivariate analysis to determine predictors of mortality.

Main Results:

  • Of 487 patients, 147 expired. Significant differences were observed in demographics and comorbidities between survivors and non-survivors.
  • Key predictors of mortality included age ≥65, initial dyspnea, cardiomyopathy, positive chest imaging findings, and acute kidney injury (AKI).
  • Age ≥65 (OR=3.87) and AKI (OR=3.33) were strongly associated with increased mortality risk.

Conclusions:

  • Identifying patients with specific risk factors (age, dyspnea, cardiomyopathy, chest imaging, AKI) is crucial for managing COVID-19.
  • Early identification of high-risk individuals can potentially improve mortality rates and guide treatment strategies.
Abstract

Keywords:
Acute kidney injuryCOVID-19CardiomyopathyMortalityRisk factors

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