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Related Experiment Videos

Glucose uptake in human adipose tissue.

P Mårin1, M Rebuffé-Scrive, U Smith

  • 1Department of Medicine I, Sahlgren's Hospital, University of Göteborg, Sweden.

Metabolism: Clinical and Experimental
|December 1, 1987
PubMed
Summary

Glucose uptake in adipose tissue is minimal, with most converted to lactate. This process may significantly impact glucose homeostasis, especially in obese individuals, with abdominal fat showing faster turnover.

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Area of Science:

  • Metabolic research
  • Human physiology
  • Obesity studies

Background:

  • Adipose tissue plays a role in glucose metabolism.
  • Understanding glucose utilization in adipocytes is crucial for metabolic health, particularly in obesity.

Purpose of the Study:

  • To quantify glucose uptake and its fate in human adipose tissue.
  • To investigate regional differences in glucose metabolism within adipose tissue.
  • To assess the contribution of adipose tissue to overall glucose homeostasis.

Main Methods:

  • Oral administration of labeled glucose (U-14C-glucose) to 17 women.
  • Needle biopsies of abdominal and femoral adipose tissue for in vitro and in vivo analysis.
  • Measurement of radioactivity in triglycerides over 7 months.

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  • In vitro studies on glucose metabolism in adipose tissue.

    • Main Results:

    • Glucose label in triglycerides was higher in abdominal than femoral adipocytes in obese women after 4 hours.
    • Triglyceride label decreased exponentially with half-lives of 12 months (abdominal) and 19 months (femoral).
    • Total body fat glucose uptake was less than 4% of administered glucose.
    • In vitro studies suggested significant glucose conversion to lactate in adipose tissue.

    Conclusions:

    • Adipose tissue glucose uptake may be significant for glucose homeostasis, especially in obese individuals, but much is released as lactate.
    • Regional differences exist, with abdominal adipocytes showing faster label turnover, consistent with higher lipolysis.
    • Adipose tissue's role in glucose homeostasis might be substantial, primarily through lactate production.