[Mesenchymal stem cells in therapy of coronavirus disease 2019 - a review]
Xiaodong Shi1, Lijia Yu1, Chunguang Ding1
1National Center for Occupational Safety and Health, National Health Commission of the People's Republic of China, Beijing 102308, China.
Abstract:
Coronavirus disease 2019 (COVID-19) has spread widely on a large scale in the whole world at present, seriously endangering human health. There are still no effective and specific drugs, so it is urgent to find safe and effective therapeutic methods. Mesenchymal stem cells (MSCs) have many biological functions of powerful immunomodulation and tissue repair and regeneration. As a stem cell therapy, it has the potential to reduce the tissue injury and mortality in severe patients infected with novel coronavirus. At present, many research institutions in China and abroad have started a number of clinical research projects about MSCs in the treatment of COVID-19. In addition, those projects have initially confirmed the safety and effectiveness of this therapy. Therefore, this research field has been proved to have a very good clinical therapy prospect.
Insights
Mesenchymal stem cells (MSCs) show promise for treating COVID-19 by reducing tissue injury and mortality. Clinical trials indicate MSC therapy is safe and effective for severe coronavirus cases.
Area of Science:
- Immunology
- Regenerative Medicine
- Infectious Diseases
Background:
- The global COVID-19 pandemic necessitates novel therapeutic strategies due to a lack of specific antiviral drugs.
- Mesenchymal stem cells (MSCs) possess potent immunomodulatory and tissue regenerative properties.
- Severe COVID-19 cases are associated with significant tissue damage and high mortality rates.
Purpose of the Study:
- To evaluate the potential of Mesenchymal Stem Cell (MSC) therapy for treating Coronavirus disease 2019 (COVID-19).
- To assess the safety and efficacy of MSCs in mitigating severe COVID-19 symptoms and improving patient outcomes.
Main Methods:
- Clinical research projects investigating MSCs for COVID-19 treatment have been initiated globally.
- Ongoing studies focus on administering MSCs to patients with severe novel coronavirus infections.
Main Results:
- Preliminary data from clinical studies suggest that MSC therapy is safe for COVID-19 patients.
- Initial findings indicate that MSC treatment may be effective in reducing tissue injury and mortality in severe cases.
Conclusions:
- Mesenchymal stem cell therapy presents a promising therapeutic avenue for managing severe COVID-19.
- Further research and clinical application of MSCs are warranted given the positive initial outcomes and potential for widespread benefit.
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