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Prehospital Thrombolysis: A Manual from Berlin
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[Recent progress in developing of thrombolytic agents for ischemic stroke]

Yanyan Xu1, Shanli Chen2, Dan Chen2

  • 1College of Biological Science and Engineering, Fuzhou University, Fuzhou 350116, Fujian, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|November 10, 2020
PubMed

Ischemic stroke is a major health crisis causing high mortality and morbidity. The key treatment relies on the rapid intervention to dissolve thrombus, to reduce bleeding side effect and re-canalize clotted blood vessels using clot lysis drugs. Tissue plasminogen activator (tPA) is the only FDA-approved drug for ischemic stroke, but it has many limitations in clinical use. In recent years, the development of thrombolytic drugs and treatment strategies based on tPA has been progressed rapidly. Here we review the recent progress in this field, including the contributions from us and others, to promote the future development of novel thrombolytic drugs.

Keywords:
ischemic strokethrombolysistissue plasminogen activator

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