AAEE minimonograph #28: injury to peripheral motor nerves

Nerve injury triggers a sequence of electrophysiological events dependent upon changes occurring both at the neuromuscular junction and the muscle membrane. The time course of these physiologic and morphologic alterations is reviewed in light of recent information provided by studies of extrajunctional acetylcholine receptors, axoplasmic transport, and freeze-fracture electron microscopy. A thorough knowledge of these changes is essential to understanding the clinical impact of nerve injury.