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FGF23 and Cause-Specific Mortality in Community-Living Individuals-The Health, Aging, and Body Composition Study
Shilpa Sharma1, Ronit Katz2, Ruth F Dubin3
1Division of Nephrology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.
Objectives:
Fibroblast growth factor (FGF)-23 is a key regulator of mineral metabolism and has been linked with left ventricular hypertrophy in animal models. Most existing epidemiologic studies evaluated a C-terminal FGF23 assay which measures both the intact (active) hormone and inactive fragments. The relationship of intact FGF23 with cause-specific mortality is unknown.
Design:
Prospective analyses of data from Health, Aging, & Body Composition (HABC) study.
Setting:
Community-living adults aged 70 to 79 years with longitudinal follow up.
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