Facile Surface Modification of Mesoporous Au Nanoparticles for Highly Sensitive SERS Detection

The stability, dispersity, and surface chemical properties of colloidal nanoparticles are crucial for the reliable and desired chemical sensing in various applications. Here, we report an effective strategy to engineer the surface properties of mesoporous Au nanoparticles (meso-Au NPs) via PVP ligand modification, template removal, and surface purification. Monodispersed 3D meso-Au NPs with well-defined sizes and shapes were obtained using a general soft-enveloping strategy. During surface modification, the addition of PVP ligands and the concentration of HF solutions play key roles in the stability, shape, and size distributions of ordered Au networks. In order to obtain an improved sensing performance, the morphologies of meso-Au NPs were optimized with smaller mesopore size, and NaBH₄ solution was used to efficiently remove the adsorbed PVP ligands. Due to the characteristics of high-density porosities and large surface area, the purified meso-Au NPs could be a kind of promising plasmonic-enhanced nanomaterial and provide abundant "hot spots." Combined with the enrichment effect using a slippery liquid-infused porous surface, the lowest detection limits of crystal violet molecule could be down to 0.1 pM, demonstrating an excellent SERS sensitivity. Moreover, a realistic illegal drug containing aspirin could be sensitively detected with a limit of 2.8 × 10^-6 M, showing great potential for practical molecular sensing and applications.