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Updated: Dec 1, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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Preeclampsia: Pathophysiology and management

R Nirupama1, S Divyashree2, P Janhavi2

  • 1Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, United States.

Journal of Gynecology Obstetrics and Human Reproduction
|November 10, 2020
PubMed

Preeclampsia is a pregnancy-related multisystem disorder, frequently encountered pregnancy-related medical complications next to gestational diabetes mellitus. It is the onset of hypertension during pregnancy. The preeclampsia can be of two types, placental or maternal preeclampsia. Among these two types former, i.e., placental preeclampsia is more severe than the latter. According to the recent survey by National Health Portal of India, the incidence of preeclampsia is about 8-10 % among pregnant women. Though our understanding of preeclampsia has improved in recent years, the development and interpretation of the clinical tests remain difficult for preeclampsia. Hence, we have made an attempt to understand the pathophysiology, associated conditions/consequences, treatment and management/prevention of the condition in this review.

Keywords:
Angiogenic-antiangiogenic factorsHypertensionPlacentaPreeclampsiaPregnancy complication

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