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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.0K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Related Experiment Video

Updated: Dec 1, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Asthma genomics and pharmacogenomics.

Michelle Daya1, Victor E Ortega2

  • 1Biomedical Informatics & Personalized Medicine, University of Colorado School of Medicine, Aurora, CO, United States.

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This review explores genetic and gene expression links to asthma and its treatments. Recent studies identify new asthma-related genes and loci, offering insights into disease mechanisms and personalized medicine.

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Area of Science:

  • Genetics and Genomics
  • Respiratory Medicine
  • Pharmacogenomics

Background:

  • Asthma is a complex respiratory disease with significant genetic and environmental influences.
  • Understanding the genetic basis of asthma is crucial for developing effective treatments.
  • Gene expression and epigenetic modifications play a role in asthma pathogenesis.

Purpose of the Study:

  • To review recent research on the relationship between genetic variation, gene expression, and asthma.
  • To summarize findings from genome-wide, transcriptome-wide, and epigenome-wide association studies in asthma.
  • To highlight pharmacogenomic studies related to asthma medications.

Main Methods:

  • Review of published genome-wide association studies (GWAS) for asthma phenotypes.
  • Analysis of transcriptome-wide association studies (TWAS) for asthma.
  • Examination of epigenome-wide association studies (EWAS) for asthma.
  • Inclusion of pharmacogenomic studies on asthma treatments.

Main Results:

  • 11 GWAS identified 64 novel asthma-associated loci.
  • TWAS revealed genes involved in immune response, inflammation, and lung remodeling.
  • EWAS identified robust, replicated findings in large cohorts.
  • Pharmacogenomic studies explored genetic influences on response to corticosteroids, albuterol, and zileuton.

Conclusions:

  • Genetic and gene expression studies have significantly advanced our understanding of asthma.
  • Novel genetic loci and genes provide targets for further research and potential therapies.
  • Pharmacogenomic findings, though preliminary, suggest potential for personalized asthma treatment.