Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does Early Opioid Use for Relief of Acute Abdominal Pain Increase Use of Abdominal CT or Prolong Emergency Department Length of Stay?

Emergency medicine international·2026
Same author

Age-dependent modulation of antioxidant defense and secondary metabolite accumulation in Solanum lycopersicum under elevated ozone stress.

Plant science : an international journal of experimental plant biology·2026
Same author

Draft genome of a '<i>Candidatus</i> Phytoplasma trifolii' -related strain BLL-Delhi associated with brinjal little leaf disease.

3 Biotech·2026
Same author

Multigene analysis reveals '<i>Candidatus</i> Phytoplasma asiaticum' (16SrII-C) association with niger and sesame phyllody in Madhya Pradesh, Central India and identification of a putative vector.

Frontiers in plant science·2026
Same author

Benchmarking free energy calculations: Analysis of single and double mutations across two simulation software platforms for two protein systems.

PloS one·2026
Same author

Draft genome sequence of "<i>Candidatus</i> Phytoplasma australasiaticum" strain TBB-AP associated with tomato big bud disease in India.

Microbiology resource announcements·2026

Related Experiment Video

Updated: Dec 1, 2025

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
07:13

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

3.6K

Direct Sciatic Nerve Electrical Stimulation for Complex Regional Pain Syndrome Type 1.

Joseph Buwembo1, Russell Munson1, Syed Ali Rizvi1

  • 1Saskatchewan Health Authority, Regina, SK, Canada.

Neuromodulation : Journal of the International Neuromodulation Society
|November 10, 2020
PubMed
Summary

Direct sciatic nerve electrical stimulation (DISNES) effectively treats complex regional pain syndrome (CRPS) foot pain, improving quality of life and reducing disability. This novel technique offers relief where spinal cord stimulation failed, particularly for disabling foot pain in CRPS I.

Keywords:
Sciatic stimulationchronic paincomplex regional pain syndromeneuromodulationperipheral nerve stimulation

More Related Videos

Author Spotlight: Unveiling the Therapeutic Effects of FSN Treatment &#8211; Bridging Research and Clinical Applications in Neuropathic Pain
08:20

Author Spotlight: Unveiling the Therapeutic Effects of FSN Treatment – Bridging Research and Clinical Applications in Neuropathic Pain

Published on: June 30, 2023

2.4K
Author Spotlight: Insights into Remotely Supervised Neuromodulation Procedure for Phantom Limb Pain
06:13

Author Spotlight: Insights into Remotely Supervised Neuromodulation Procedure for Phantom Limb Pain

Published on: March 1, 2024

1.6K

Related Experiment Videos

Last Updated: Dec 1, 2025

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
07:13

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

3.6K
Author Spotlight: Unveiling the Therapeutic Effects of FSN Treatment &#8211; Bridging Research and Clinical Applications in Neuropathic Pain
08:20

Author Spotlight: Unveiling the Therapeutic Effects of FSN Treatment – Bridging Research and Clinical Applications in Neuropathic Pain

Published on: June 30, 2023

2.4K
Author Spotlight: Insights into Remotely Supervised Neuromodulation Procedure for Phantom Limb Pain
06:13

Author Spotlight: Insights into Remotely Supervised Neuromodulation Procedure for Phantom Limb Pain

Published on: March 1, 2024

1.6K

Area of Science:

  • Neurology
  • Pain Management
  • Medical Devices

Background:

  • Complex Regional Pain Syndrome (CRPS) often causes debilitating foot and leg pain.
  • Conventional treatments and spinal cord stimulation (SCS) may not fully alleviate pain, especially in the foot.
  • Neuromodulation offers potential for managing refractory CRPS pain.

Purpose of the Study:

  • To evaluate the efficacy of direct sciatic nerve electrical stimulation (DISNES) for intractable foot and leg pain in patients with CRPS I.
  • To compare DISNES outcomes with previous SCS treatments in a subset of patients.
  • To assess the impact of DISNES on pain, disability, quality of life, and autonomic features.

Main Methods:

  • A cohort of 16 patients with CRPS I and intractable foot/leg pain underwent ipsilateral DISNES.
  • Patients had previously failed conventional medical management; 7 had prior SCS treatment.
  • Outcomes were measured using Visual Analog Scale (VAS), Oswestry Disability Index (ODI), EQ-5D, and SF-36 scores.

Main Results:

  • Significant reductions in VAS pain scores (59% at F/U 1, 46% at F/U 2) and ODI (40% at F/U 1, 37% at F/U 2) were observed.
  • Quality of life scores (SF-36, EQ-5D) showed significant improvements.
  • Rapid resolution of autonomic symptoms (edema, hyperemia, allodynia) within 7-10 days occurred; 3 patients returned to work.

Conclusions:

  • DISNES is effective in managing disabling foot pain associated with CRPS I.
  • The technique improves quality of life, ambulation, and reduces disability in CRPS patients.
  • DISNES also alleviates autonomic features and dystonia, though further long-term studies are warranted.