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Urotensin-II, oxidative stress, and inflammation increase in hypertensive and resistant hypertensive patients

Eray Metin Guler1, Mustafa Gokce2, Ahmet Bacaksiz3

  • 1Department of Medical Biochemistry, Bezmialem Vakif University School of Medicine , Istanbul, Turkey.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|November 11, 2020
PubMed

Insights

Hypertension and resistant hypertension are linked to higher Urotensin-II, oxidative stress, and inflammation markers. Lower antioxidant and thiol levels are observed in hypertensive patients compared to normotensive controls.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Clinical Research

Background:

  • Hypertension is a global health issue with complex underlying mechanisms.
  • Urotensin-II (UII), oxidative stress, and inflammation are implicated in cardiovascular health.
  • Understanding these factors is crucial for managing hypertension and its resistant forms.

Purpose of the Study:

  • To investigate Urotensin-II (UII), oxidative stress, and inflammation markers in normotensive, hypertensive, and resistant hypertensive patients.
  • To compare levels of these biomarkers across different blood pressure categories.
  • To elucidate the role of UII, oxidative stress, and inflammation in resistant hypertension.

Main Methods:

  • A comparative study involving 50 resistance hypertensive (rHT), 50 hypertensive (HT), and 50 normotensive (NT) control participants.
  • Measurement of serum Urotensin-II (UII), total oxidant status (TOS), total antioxidant status (TAS), thiol/disulfide balance (NT, TT, DIS), inflammatory cytokines (IL1β, IL6, TNFα, hsCRP), and lipid profiles (HDL, LDL, TC).

Main Results:

  • Serum UII, IL1β, IL6, TNFα, DIS, TOS, and OSI were significantly higher in HT and rHT groups compared to NT controls (p < .001).
  • Serum TT, TAS, and NT levels were significantly lower in HT and rHT groups compared to NT controls (p < .001).
  • Levels of TC, hsCRP, TOS, OSI, UII, IL1β, IL6, and TNFα increased from HT to rHT, while TAS and NT levels decreased (p < .001).

Conclusions:

  • Urotensin-II levels, oxidative stress, and inflammation are elevated in hypertensive and resistant hypertensive individuals.
  • Antioxidant and thiol levels are diminished in hypertensive patients.
  • Resistant hypertension is associated with a greater degree of impaired antioxidant status, increased oxidative stress, and free radical activity.

Keywords:
Resistant hypertensioninflammationoxidative stressurotensin-II

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