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Risk factors for recurrent respiratory tract infection in preschool-aged children

Bo Zhou1,2,3, Wenquan Niu4, Fangyu Liu1

  • 1Graduate School, Beijing University of Chinese Medicine, Beijing, China.

Pediatric Research
|November 11, 2020
PubMed

Insights

Asthma, allergies, early antibiotic use, and short breastfeeding duration are key risk factors for recurrent respiratory infections in Chinese preschoolers. These factors, along with maternal BMI, can predict infection risk.

Area of Science:

  • Pediatrics
  • Epidemiology
  • Public Health

Background:

  • Recurrent respiratory tract infections (RRTIs) pose a significant health burden in preschool-aged children.
  • Identifying risk factors is crucial for targeted prevention strategies.

Purpose of the Study:

  • To identify potential risk factors for RRTIs in Chinese preschool children.
  • To develop a predictive model for RRTIs.

Main Methods:

  • A cross-sectional survey was conducted in Beijing involving 7222 children from 20 kindergartens.
  • Stratified cluster random sampling was employed.
  • Data were analyzed using STATA and R language.

Main Results:

  • Five independent factors were significantly associated with RRTI risk: asthma (OR=8.31), allergy (OR=2.31), initial antibiotic use <6 months (OR=1.72), breastfeeding duration <6 months (OR=1.24), and maternal BMI (OR=1.19).
  • Asthma emerged as the leading risk factor.
  • Allergy, early antibiotic exposure, and limited breastfeeding showed a graded, dose-dependent effect on susceptibility.

Conclusions:

  • Five key risk factors for RRTI were identified in Chinese preschoolers.
  • Asthma is a primary determinant, while other factors contribute in a dose-dependent manner, informing targeted interventions.
Abstract

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