Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Illustration of transfer learning from breast cancer detection to risk prediction: adaptation to local data and local objectives.

Journal of medical imaging (Bellingham, Wash.)·2026
Same author

Improving the Somatostatin Receptor Status Assessment for Personalized and Precise Management of Neuroendocrine Neoplasms with the Use of a <sup>99m</sup>Tc-Radiolabeled Somatostatin Receptor Antagonist: The Final Results of the ERA PerMed TECANT Clinical Trial.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Probabilistic clinical target definition with nearest neighbor correlation.

Physics in medicine and biology·2025
Same author

Differential Clearance of [<sup>177</sup>Lu]Lu-PSMA-617 from Metastatic Prostate Cancer Lesions and Normal Tissues creates a Window for Safe Application of DNA Repair Inhibitors.

medRxiv : the preprint server for health sciences·2025
Same author

Apparent Diffusion Coefficient Magnetic Resonance Imaging as a Predictive Biomarker for Hypoxia, Treatment De-escalation, and Recurrence in Human Papillomavirus-Associated Oropharyngeal Cancer.

International journal of radiation oncology, biology, physics·2025
Same author

Prospective validation of a pretreatment 18F-FDG PET/CT and mean lung dose model for early radiation pneumonitis.

Physics and imaging in radiation oncology·2025

Related Experiment Video

Updated: Dec 1, 2025

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice
08:42

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice

Published on: July 26, 2024

1.5K

Evaluation of a high resolution silicon PET insert module.

Milan Grkovski1,2, Karol Brzezinski3, Vladimir Cindro1

  • 1Jožef Stefan Institute, Ljubljana, Slovenia.

Nuclear Instruments & Methods in Physics Research. Section A, Accelerators, Spectrometers, Detectors and Associated Equipment
|November 11, 2020
PubMed
Summary
This summary is machine-generated.

A novel high-resolution positron emission tomography (PET) insert module significantly enhances image quality near its surface. This advancement offers improved diagnostic capabilities with a moderate technological investment.

Keywords:
Image reconstructionPET insertPositron emission tomographySilicon detectors

More Related Videos

Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology
09:58

Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology

Published on: July 21, 2018

23.7K
A Silicon-tipped Fiber-optic Sensing Platform with High Resolution and Fast Response
09:03

A Silicon-tipped Fiber-optic Sensing Platform with High Resolution and Fast Response

Published on: January 7, 2019

7.5K

Related Experiment Videos

Last Updated: Dec 1, 2025

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice
08:42

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice

Published on: July 26, 2024

1.5K
Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology
09:58

Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology

Published on: July 21, 2018

23.7K
A Silicon-tipped Fiber-optic Sensing Platform with High Resolution and Fast Response
09:03

A Silicon-tipped Fiber-optic Sensing Platform with High Resolution and Fast Response

Published on: January 7, 2019

7.5K

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • High-Resolution PET Imaging

Background:

  • Conventional Positron Emission Tomography (PET) systems have limitations in resolving small structures.
  • Augmenting conventional PET with close-proximity detectors can potentially improve image quality in specific regions of interest.

Purpose of the Study:

  • To develop and evaluate a high-resolution PET insert module for augmenting conventional PET systems.
  • To quantify the added benefit of such a PET insert module on image reconstruction quality.

Main Methods:

  • Developed a PET insert module with two 1 mm thick silicon sensors (1040 1 mm² pads each).
  • Utilized 16 VATAGP7.1 ASICs and a custom data acquisition board for signal readout.
  • Acquired data using a Jaszczak phantom filled with 18F-FDG and reconstructed images with the Maximum Likelihood Expectation Maximization (ML-EM) method.

Main Results:

  • The PET insert module demonstrated a substantial improvement in reconstructed image quality near its surface.
  • The contribution of high-resolution data from the insert was estimated to be approximately 4% of the total data.
  • Full and limited angular coverage data, along with three coincidence event types, were analyzed.

Conclusions:

  • The developed high-resolution PET insert module effectively enhances image quality in regions proximal to the insert.
  • Achieving similar image quality improvements may be feasible with two insert modules (4 mm effective sensor thickness) at a moderate cost.
  • This technology holds promise for improving diagnostic accuracy in specific clinical applications requiring high spatial resolution.