Related Experiment Videos
Long-term treatment with captopril in paediatric patients with severe hypertension and chronic renal failure
L Callis1, A Vila, J Castellanos
1Department of Paediatric Nephrology, Hospital Infantil Valle de Hebr¿on , Barcelona, Spain.
Insights
Captopril effectively managed hypertension in children with end-stage renal failure undergoing chronic hemodialysis. This study indicates captopril is well-tolerated and suitable for long-term pediatric use in managing renal failure complications.
Area of Science:
- Pediatric Nephrology
- Pharmacology
- Hypertension Management
Background:
- End-stage renal failure (ESRF) in children often presents with difficult-to-manage hypertension.
- Chronic hemodialysis is a life-sustaining treatment for pediatric ESRF but can be associated with cardiovascular complications like hypertension.
Purpose of the Study:
- To evaluate the efficacy and safety of captopril for long-term hypertension control in pediatric patients with ESRF on chronic hemodialysis.
Main Methods:
- A cohort of 42 children with ESRF and hypertension on chronic hemodialysis received captopril.
- Treatment duration ranged from 18 to 78 months.
- Dosing varied from 0.3 to 3.0 mg/kg every 24 or 48 hours.
Main Results:
- Satisfactory blood pressure control was achieved in all treated patients.
- Captopril demonstrated good tolerance in the pediatric population.
- The drug was effective across a range of dosages and administration frequencies.
Conclusions:
- Captopril is an effective and well-tolerated medication for managing hypertension in children with end-stage renal failure undergoing chronic hemodialysis.
- The findings support the long-term use of captopril in this specific pediatric patient group.
Abstract:
Forty two children with end stage renal failure and hypertension on chronic haemodialysis have been treated with captopril for from 18 to 78 months. Satisfactory control has been obtained in doses of 0.3 to 3.0 mg/kg given every 24 or 48 hours. Tolerance was good. The results of the present study suggest that captopril is a suitable drug for long-term use in paediatric patients.