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Updated: Dec 1, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
Determining the relationship between SARS-CoV-2 infection, dopamine, and COVID-19 complications
Muad M Khalefah1, Ayman M Khalifah2
1Department of Biology, King Abdulaziz University, CSAR, Rabigh, KSA.
Objectives:
There is compelling evidence that aged, immunosuppressed, and chronically ill patients are a high-risk group for increased mortality upon infection with the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study investigated the contribution of morbidities and related prescribed medications to COVID-19 associated mortality.
Methods:
Based on the various recently reported clinical scenarios a theoretical framework was designed to shed light on the mode of infection of the central nervous system by SARS-CoV-2 and possible management options.
Results:
Dopamine-release mechanisms in the central nervous system may play a major role in the entry and propagation of coronaviruses.
Conclusion:
This study emphasizes the need for a thorough and urgent investigation of the dopamine-release pathways in the central nervous system. These efforts will help find a definitive cure for the pandemic coronavirus disease (COVID-19).
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