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Beneficial Roles of Microglia and Growth Factors in MS, a Brief Review

Vincent Pons1, Serge Rivest1

  • 1Neuroscience Laboratory, Department of Molecular Medicine, Faculty of Medicine, CHU de Québec Research Center, Laval University, Québec City, QC, Canada.

Frontiers in Cellular Neuroscience
|November 11, 2020
PubMed

Insights

Microglia, the brain immune cells, produce growth factors (GFs) that aid neuronal repair. This review explores how microglia and GFs influence myelin regeneration in multiple sclerosis.

Area of Science:

  • Neuroimmunology
  • Cellular Biology
  • Neuroregeneration

Background:

  • Microglia are the central nervous system's resident immune cells.
  • They produce various growth factors (GFs) crucial for neuronal health and recovery.
  • Microglia exhibit dual roles (beneficial and detrimental) in neurodegenerative diseases, including multiple sclerosis (MS).

Purpose of the Study:

  • To review the role of microglia and GFs in myelin repair processes.
  • To understand the influence of microglia on remyelination (RM) following demyelination (DM).

Main Methods:

  • Literature review of recent studies on microglia, GFs, and myelin repair.
  • Analysis of the interplay between microglial functions and regenerative processes in demyelinating diseases.

Main Results:

  • Microglia are implicated in both demyelination (DM) and remyelination (RM) in MS.
  • Emerging evidence highlights a beneficial role for microglia in promoting myelin regeneration.
  • Growth factors produced by microglia are key mediators of this regenerative capacity.

Conclusions:

  • Microglia possess a significant capacity to influence remyelination.
  • Targeting microglial functions and growth factor production may offer therapeutic strategies for enhancing myelin repair in MS.
Keywords:
growth factorsinnate immnuitymicroglia 1multiplesclerosisremyelination

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