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COVID-19 Related Cerebrovascular Thromboembolic Complications in Three Young Patients

Khawaja Hassan Haroon1,2, Ahmad Muhammad1,2, Suhail Hussain1

  • 1Neuroscience Institute, Hamad Medical Corporation, Doha, Qatar.

Case Reports in Neurology
|November 11, 2020
PubMed

Insights

Patients with Coronavirus disease 2019 (COVID-19) face a higher risk of developing blood clots. This increased thrombosis risk is linked to excessive inflammation and platelet activation caused by the SARS-CoV-2 virus.

Area of Science:

  • * Infectious Diseases and Virology
  • * Hematology and Thrombosis

Background:

  • * The global pandemic of Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, presents significant challenges to healthcare systems worldwide.
  • * COVID-19 is increasingly recognized for its association with coagulopathy, affecting both venous and arterial vascular systems.

Observation:

  • * Patients diagnosed with COVID-19 exhibit a heightened susceptibility to thrombotic events.
  • * The pathophysiology involves a complex interplay of excessive inflammation, platelet hyper-reactivity, and endothelial cell dysfunction.

Findings:

  • * SARS-CoV-2 infection triggers a pro-thrombotic state, increasing the risk of blood clot formation.
  • * Mechanisms contributing to COVID-19-related coagulopathy include systemic inflammation, platelet activation, endothelial injury, and venous stasis.

Implications:

  • * Understanding the mechanisms of COVID-19-associated thrombosis is crucial for developing effective prevention and treatment strategies.
  • * Clinical management of COVID-19 patients should consider the elevated risk of venous thromboembolism (VTE) and arterial thrombosis.

Keywords:
COVIDCerebral infarctionCerebral venous thrombosisStrokeThromboembolic complications

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