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Longer Cortical Silent Period Length Is Associated to Binge Eating Disorder: An Exploratory Study.

Luciana C Antunes¹, Jessica Lorenzzi Elkfury², Cristiane Schultz Parizotti²

¹Associate Professor in the Health Science Center, Nutrition Department, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Brazil.

Frontiers in Psychiatry

|November 11, 2020

Summary

Binge eating disorder (BED) patients exhibit longer cortical silent periods (CSP), indicating increased motor cortex inhibition. This CSP measure correlates with eating concerns and binge eating severity, suggesting a potential neural marker for BED.

Keywords:

binge-eating disorder cortical excitability eating behavior eating disorders executive function obesity

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Area of Science:

Neuroscience
Psychiatry
Clinical Medicine

Background:

Binge eating disorder (BED) and obesity share disrupted eating behavior pathways.
Understanding neural substrates like motor cortex excitability may illuminate BED and obesity pathophysiology.
Transcranial magnetic stimulation (TMS) offers a method to assess motor cortex excitability.

Purpose of the Study:

To compare cortical excitability, specifically the cortical silent period (CSP), between BED, obese, ex-obese, and healthy control (HC) groups using TMS.
To investigate the relationship between CSP, eating behaviors, depressive symptoms, and sleep quality across these groups.

Main Methods:

Fifty-nine women (BED, obese, ex-obese, HC) underwent TMS to measure CSP, SICI, and ICF.
Participants completed assessments for eating psychopathology (e.g., Three-Factor Eating Questionnaire, Binge Eating Scale) and inhibition via a Go/No-go task.

Main Results:

The BED group exhibited significantly longer CSP compared to obesity, HC, and ex-obese groups.
CSP was positively correlated with eating concern and binge eating scores.
No significant differences were found in SICI or ICF between groups.

Conclusions:

Longer CSP in BED patients suggests potential upregulation of intracortical inhibition.
CSP may serve as a neurophysiological marker associated with binge eating severity and related concerns.
Further research is warranted to explore the clinical implications of these findings.