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Gut bioengineering strategies for regenerative medicine
John D O'Neill1,2, Meghan R Pinezich1, Brandon A Guenthart3
1Department of Biomedical Engineering, Columbia University, New York, New York.
American Journal of Physiology. Gastrointestinal and Liver Physiology
|November 11, 2020
Summary
Bioengineering strategies offer new ways to model gastrointestinal diseases and regenerate gut tissues. Advances in gut bioengineering aim to improve disease modeling and regenerative medicine for better patient outcomes.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Gastroenterology
Background:
- Rising global burden of gastrointestinal diseases necessitates innovative therapeutic strategies.
- Current limitations exist in developing predictive in vitro models and effective in vivo regenerative therapies for the gut.
Purpose of the Study:
- To review emerging bioengineering tools and recent advances in gut bioengineering.
- To identify challenges and opportunities in applying these technologies for disease modeling and regenerative medicine.
Main Methods:
- Survey of current gut bioengineering toolkit.
- Analysis of methodologies for de novo tissue generation and in vivo regeneration.
- Review of progress in intestinal organoid cultures and engineered tissues.
Main Results:
- Significant progress in generating gutlike tissues and engineered constructs.
- Ongoing challenges in creating predictive in vitro models and achieving effective in vivo gut regeneration.
- Identification of key areas for future research and development.
Conclusions:
- Gut bioengineering holds promise for advancing gastrointestinal disease modeling and regenerative medicine.
- Further innovation is needed to overcome current challenges in predictive modeling and therapeutic regeneration.
- The field presents opportunities for improved clinical outcomes in treating gut disorders.
