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Why does COVID-19 pathology have several clinical forms?

Fatemeh Aliabadi1, Marjan Ajami2, Hamidreza Pazoki-Toroudi1,3

  • 1Physiology Research Center, Department of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|November 11, 2020
PubMed

Insights

This study explores how prostaglandin E2 (PGE2) may worsen COVID-19 outcomes. Researchers propose PGE2

Area of Science:

  • Virology
  • Immunology
  • Pathology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, necessitates understanding viral pathology for effective treatments and vaccines.
  • SARS-CoV-2 infection can affect multiple organs, with mechanisms not fully elucidated.
  • Prostaglandin E2 (PGE2) is implicated in inflammation and immunity, and its dysregulation may contribute to severe COVID-19.

Purpose of the Study:

  • To investigate the role of prostaglandin E2 (PGE2) in the diverse side effects observed in SARS-CoV-2 infections.
  • To determine if PGE2 is a significant causative factor in COVID-19 pathology.
  • To propose a mechanism for increased PGE2 production during COVID-19 and its correlation with disease severity.

Main Methods:

  • Review and analysis of existing literature on SARS-CoV-2 pathology and prostaglandin E2 pathways.
  • Correlation of reported COVID-19 side effects with known PGE2-mediated inflammatory responses.
  • Hypothesizing a mechanistic link between SARS-CoV-2 infection and elevated PGE2 levels.

Main Results:

  • PGE2 is involved in various inflammation and immunity pathways that can be exacerbated during SARS-CoV-2 infection.
  • Elevated PGE2 expression may contribute to a cytokine storm, leading to multi-organ damage.
  • A potential mechanism linking COVID-19 disease to increased PGE2 production is proposed.

Conclusions:

  • Prostaglandin E2 (PGE2) is a potential key factor in the pathology and severity of COVID-19.
  • Understanding the PGE2 pathway in SARS-CoV-2 infection could guide therapeutic strategies.
  • Further research is warranted to confirm the direct relationship between PGE2 levels and COVID-19 disease severity.
Keywords:
COVID-19coronavirusesdrug discoveryoutbreakpathologyprostaglandin E2 (PGE2)

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