Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

1.3K
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of GBA1 status and sex with depression severity and progression in Parkinson's disease.

NPJ Parkinson's disease·2026
Same author

Hippocampal-cortical structural networks in the progression of cognitive impairment: A source-based morphometry analysis in individuals with subjective cognitive decline, mild cognitive impairment and Alzheimer's disease.

Neurobiology of aging·2026
Same author

Levodopa-induced dyskinesia is associated with worse gait and balance in Parkinson's disease.

Journal of neural transmission (Vienna, Austria : 1996)·2026
Same author

Shaping the cognitive reserve: the role of lifelong enrichment and education in the Alzheimer's disease continuum.

Frontiers in aging neuroscience·2026
Same author

Precision pathways: optimising amyloid PET for sustainable Alzheimer's disease care.

Journal of neurology·2026
Same author

Age-adjusted neurofilament light chain cutoffs for diagnosing neurodegenerative dementia: a two-threshold machine learning approach.

GeroScience·2026

Related Experiment Video

Updated: Dec 1, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.9K

Detection of Alzheimer's Disease using cortical diffusion tensor imaging.

Mario Torso1,2, Marco Bozzali3,4, Giovanna Zamboni1,5

  • 1Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Human Brain Mapping
|November 11, 2020
PubMed
Summary

A new in-vivo brain MRI analysis method accurately detects cortical grey matter changes in Alzheimer's Disease (AD) patients. This tool aids in assessing neurodegeneration and distinguishing AD from healthy controls.

Keywords:
Alzheimer's Diseasecortical diffusion tensor imagingcortical microstructurediagnostic accuracyminicolumn

More Related Videos

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

25.6K
Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

8.8K

Related Experiment Videos

Last Updated: Dec 1, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.9K
Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

25.6K
Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

8.8K

Area of Science:

  • Neuroimaging
  • Neurology
  • Medical Diagnostics

Background:

  • Alzheimer's Disease (AD) is characterized by progressive neurodegeneration.
  • Current diagnostic methods for AD can be invasive or costly.
  • There is a need for non-invasive tools to assess cortical changes in AD.

Purpose of the Study:

  • To evaluate a novel in-vivo brain MRI analysis technique for detecting cortical architecture alterations in Alzheimer's Disease (AD).
  • To validate the method's accuracy in distinguishing AD patients from healthy controls across multiple cohorts.
  • To explore the potential of this MRI method within the Amyloid, Tau, Neurodegeneration (ATN) framework.

Main Methods:

  • Utilized three distinct cohorts: Discovery, Test, and an ADNI 3 cohort (ATN framework).
  • Applied a novel in-vivo brain MRI analysis method to assess cortical grey matter quality.
  • Compared MRI findings with amyloid and Tau Positron Emission Tomography (PET) data in the ATN cohort.

Main Results:

  • The MRI analysis method successfully identified altered cortical grey matter quality in AD patients.
  • The method demonstrated good to excellent accuracy in differentiating AD patients from healthy controls.
  • The technique showed potential as an index of cortical microstructure quality and a marker of neurodegeneration.

Conclusions:

  • The novel in-vivo brain MRI method offers a valuable tool for assessing Alzheimer's Disease.
  • This technique can serve as an objective measure of neurodegeneration within the ATN classification system.
  • Further development could enhance AD diagnosis, patient stratification, and treatment monitoring in clinical trials.