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Functional mechanism and clinical implications of MicroRNA-423 in human cancers

RuiSheng Ke1,2, LiZhi Lv2,3, SiYu Zhang1

  • 1Department of General Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, China.

Cancer Medicine
|November 11, 2020
PubMed

Insights

MicroRNA-423 (miR-423) shows a dual role in cancer, acting as both an oncomiR and anticancer agent. Understanding its complex functions and interactions is key for developing diagnostic and therapeutic strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Regulation

Background:

  • MicroRNAs regulate gene expression and are implicated in tumorigenesis.
  • Aberrant expression of microRNA-423 (miR-423) is observed in various human cancers.
  • miR-423's role in cancer progression involves multiple signaling pathways.

Purpose of the Study:

  • To review the dual role of miR-423 in tumorigenesis.
  • To summarize the mechanisms underlying miR-423's paradoxical functions in cancer.
  • To explore the therapeutic potential of miR-423 in human tumors.

Main Methods:

  • Literature review of studies on miR-423 in human cancers.
  • Analysis of miR-423 expression patterns and functional roles.
  • Investigation of miR-423's interaction with long non-coding RNAs (lncRNAs).

Main Results:

  • miR-423 exhibits contradictory roles, acting as both an oncomiR and an anticancer miRNA.
  • Its aberrant expression influences multiple cancer-related signaling pathways.
  • The interaction between miR-423 and lncRNAs is a critical area requiring further investigation.

Conclusions:

  • The dual role of miR-423 presents challenges for its application as a diagnostic or therapeutic target.
  • Further research into miR-423's mechanisms and interactions is essential for clinical translation.
  • miR-423 holds potential for cancer therapy, contingent on a comprehensive understanding of its functions.
Keywords:
MicroRNA-423clinical implicationsfunctional mechanismtumorigenesis

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