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Application of NaYF4:Yb/Er/Tm UCNPs in Array-Based Sensing of Neurotransmitters: From a Single Particle to a
Samira Abbasi-Moayed1, Arafeh Bigdeli1, Mohammad Reza Hormozi-Nezhad1,2
1Chemistry Department, Sharif University of Technology, Tehran 11155-9516, Iran.
Abstract:
A novel multichannel sensor array has been designed using a single, yet multiemissive lanthanide-doped upconversion nanoparticle (UCNP). The energy levels of lanthanide ions gave rise to several emission bands which were exploited as individual sensor elements for the recognition of four important neurotransmitters (NTs): dopamine, norepinephrine, levodopa, and serotonin. At alkaline conditions, the oxidation products of these NTs quenched the fluorescence emissions of UCNPs with different quenching degrees. The resulting fingerprint multichannel emission profiles from NaYF4:Yb/Er/Tm UCNPs allowed the discrimination of NTs with excellent accuracy. The recognition was further verified in artificial cerebrospinal fluid, as a complex biological media. We believe that the designed UCNP-based multichannel sensor array offers innovative insights into the discrimination of various chemical signatures using a single measurement.
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