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Modular Peptide Probe for Pre/Intra/Postoperative Therapeutic to Reduce Recurrence in Ovarian Cancer.
Jun Dai1, Yong Cheng2, Jun Wu2
1Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430032, China.
ACS Nano
|November 11, 2020
Summary
A novel modular peptide probe system (PIP) effectively reduces ovarian cancer recurrence by combining preoperative, intraoperative, and postoperative therapies. This innovative approach targets tumor cells and inhibits angiogenesis, offering a new strategy for surgical management.
Area of Science:
- Biomedical Engineering
- Oncology
- Nanotechnology
Background:
- Ovarian cancer recurrence remains high (80%) despite optimal surgery.
- Current adjuvant therapies show limited efficacy in preventing tumor recurrence.
Purpose of the Study:
- To develop a modular peptide probe-based therapeutic system (PIP) to reduce ovarian cancer recurrence.
- To investigate the efficacy of a multi-stage therapeutic strategy involving preoperative, intraoperative, and postoperative interventions.
Main Methods:
- Design of a modular peptide probe (TCDTMP) capable of self-assembling into nanoparticles (NPs).
- Loading NPs with miR-145-5p for preoperative apoptosis induction and VEGF-siRNA for postoperative anti-angiogenesis.
- Integration of TCDTMP/miR-145-5p with photodynamic therapy (PDT) for intraoperative residual tumor elimination.
Main Results:
- Preoperative TCDTMP/miR-145-5p actively targeted tumors, induced apoptosis, and increased miR-145-5p expression.
- Intraoperative PDT effectively eliminated microscopic residual tumors post-surgery.
- Postoperative TCDTMP/VEGF-siRNA suppressed tumor recurrence through anti-angiogenesis.
Conclusions:
- The PIP therapeutic system significantly reduced ovarian cancer recurrence in various preclinical models.
- This modular peptide probe-based system offers a promising perspective for improving ovarian cancer surgical management.
