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Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
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Corticosteroid associated lupus pancreatitis.

Semra Demirli Atıcı1, Ömer Engin1, Göksever Akpınar1

  • 1University of Health Sciences, Tepecik Training and Research Hospital, Department of General Surgery, İzmir, Turkey.

Revista Da Associacao Medica Brasileira (1992)
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Glucocorticoid therapy, particularly pulse steroids, may trigger acute pancreatitis in patients with systemic lupus erythematosus. This condition can present with abdominal pain, even with normal serum amylase and lipase levels.

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Area of Science:

  • Internal Medicine
  • Gastroenterology
  • Rheumatology

Background:

  • The link between glucocorticoid administration and acute pancreatitis is not well-established.
  • Existing cases often involve confounding systemic vascular diseases like systemic lupus erythematosus (SLE).

Observation:

  • A 22-year-old female diagnosed with SLE presented with eye involvement.
  • She received pulse intravenous methylprednisolone followed by oral prednisolone.
  • During treatment, she developed acute abdominal pain, distention, nausea, and vomiting, suggestive of peritonitis.

Findings:

  • Abdominal CT scan showed perihepatic and perisplenic fluid with mesenteric heterogeneity.
  • Exploratory laparotomy revealed diffuse abdominal fluid and pancreatic edema.
  • Intra-abdominal fluid analysis showed elevated amylase and lipase levels.

Implications:

  • Acute pancreatitis should be considered in the differential diagnosis of new-onset abdominal pain in patients undergoing pulse steroid therapy, even with normal serum amylase and lipase.
  • This case highlights a potential adverse effect of glucocorticoids that requires clinical vigilance.
  • Careful dose reduction of steroids may be necessary in such cases.