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Preliminary study between Y chromosome haplogroups and chagasic cardiomyopathy manifestations in patients with Chagas

Oscar Lassen1, Sandra Tabares2, Patricia Bertolotto3

  • 1Cordoba Hospital, Semiology Department UHMI 3, Chagas and Hypertension Office, Córdoba, Argentina.

Revista Da Sociedade Brasileira De Medicina Tropical
|November 11, 2020
PubMed

Insights

The Y chromosome's R1b haplogroup may offer cardiovascular protection in men with Chagas disease. This finding suggests a potential genetic factor influencing disease severity and outcomes in affected males.

Area of Science:

  • Genetics
  • Immunology
  • Tropical Medicine

Background:

  • Chagas disease disproportionately affects men, leading to more severe pathological symptoms.
  • The role of the Y chromosome and its haplogroups in Chagas disease pathogenesis remains underexplored.
  • Understanding genetic factors can help predict disease progression and identify potential therapeutic targets.

Purpose of the Study:

  • To investigate the influence of Y chromosome haplogroups on Chagas disease severity in men.
  • To assess the association between Y chromosome ancestry and clinical presentation of Chagas disease.
  • To explore potential protective genetic markers for cardiovascular complications.

Main Methods:

  • Comparative analysis of 150 men with Chagas disease (CD) and 150 men with non-chagasic disease (nCD).
  • Assessment of serological diagnosis, clinical parameters, and cardiac function (echocardiography, electrocardiogram).
  • Y chromosome haplogroup determination using 17 microsatellite markers and logistic regression analysis.

Main Results:

  • The R1b haplogroup was more prevalent in the non-chagasic disease group, while G2a was more common in the Chagas disease group.
  • Men with the R1b haplogroup exhibited fewer clinical signs of Chagas disease.
  • Absence of the R1b haplogroup increased the likelihood of cardiac alterations (cardio-thorax index >0.5% and EcoCG alterations) in Chagas disease patients.

Conclusions:

  • The R1b Y chromosome haplogroup may confer a protective cardiovascular effect in men with Chagas disease.
  • Y chromosome haplogroup analysis could aid in stratifying Chagas disease patients by cardiovascular risk.
  • Further research is warranted to elucidate the mechanisms behind this potential protective effect.
Abstract

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