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Unravelling the puzzle of antithrombotic therapies for complex percutaneous coronary intervention

Leonardo De Luca1, Marco Valgimigli2

  • 1Division of Cardiology, Department of Cardiosciences, A.O. San Camillo-Forlanini, Circonvallazione Gianicolense, 87, 00152 Roma, Italy.

European Heart Journal. Cardiovascular Pharmacotherapy
|November 11, 2020
PubMed

Insights

Optimal antithrombotic strategies are crucial for patients undergoing complex percutaneous coronary intervention (PCI). This review examines recent evidence to define the best adjunctive antithrombotic regimens for complex PCI, aiming to reduce complications and improve outcomes.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Pharmacology

Background:

  • Percutaneous coronary intervention (PCI) has advanced significantly, leading to increased treatment of complex coronary lesions.
  • Complex PCI is linked to higher procedural risks and adverse clinical events.

Purpose of the Study:

  • To review and discuss current evidence on antithrombotic therapies for patients undergoing complex PCI.
  • To identify optimal adjunctive antithrombotic regimens in this high-risk population.

Main Methods:

  • Systematic review of recent studies and analyses.
  • Appraisal of antithrombotic treatment strategies in the context of complex PCI.

Main Results:

  • Complex PCI is associated with increased procedural complications and adverse outcomes.
  • Optimal antithrombotic regimens for complex PCI require further definition based on emerging evidence.

Conclusions:

  • Evidence suggests a need for tailored antithrombotic approaches in complex PCI.
  • Further research is warranted to establish definitive guidelines for antithrombotic therapy in complex PCI settings.

Keywords:
Anticoagulation therapyAspirinCangrelorClopidogrelComplex PCIDual antiplatelet therapyRivaroxabanTicagrelorUnfractioned heparin

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