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Normative values for SedLine-based processed electroencephalography parameters in awake volunteers: a prospective
Alessandro Belletti1,2, Thummaporn Naorungroj3,4, Fumitaka Yanase3,5
1Department of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia. belletti.ale@gmail.com.
Journal of Clinical Monitoring and Computing
|November 11, 2020
Summary
New SedLine device baseline values were established in awake adults. Eyes open significantly alters SedLine parameters, likely due to increased EMG activity, impacting clinical interpretation.
Area of Science:
- Neuroscience
- Anesthesiology
- Biomedical Engineering
Background:
- Processed electroencephalography (pEEG) monitors anesthesia and sedation depth.
- A novel SedLine device is now in clinical use.
- Baseline SedLine data for awake adults are lacking.
Purpose of the Study:
- Determine baseline SedLine parameters in awake adults.
- Compare eyes-open versus eyes-closed states.
- Investigate factors influencing SedLine readings.
Main Methods:
- Prospective observational study in 50 healthy volunteers.
- Recorded SedLine parameters for 2 minutes (eyes closed) and 8 minutes (eyes open).
- Analyzed changes between states and correlations with EMG and other factors.
Main Results:
- Median Patient State Index (PSI) was higher with eyes open (94) than eyes closed (88).
- Electromyography (EMG) activity was significantly higher with eyes open (47.2%) versus eyes closed (28.6%).
- EMG correlated positively with PSI when eyes were closed, but not when open.
Conclusions:
- Eyes-open state significantly alters SedLine parameters in awake individuals.
- Increased EMG activity, such as from eye blinking, is a likely cause.
- Findings are crucial for accurate clinical interpretation of SedLine PSI and future research design.
