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Design and analysis of biomarker-integrated clinical trials with adaptive threshold detection and flexible patient

Ting Wang1, Xiaofei Wang2, Stephen L George2

  • 1Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Journal of Biopharmaceutical Statistics
|November 11, 2020
PubMed

Keywords:
adaptive threshold estimationbiomarker-integrated clinical trialscontinuous biomarkermulti-stage designpatient enrichmentpredictive probability of successtesting and estimation of treatment effects

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