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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
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Papillary Dermis01:11

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Spinal Nerves: Plexus I01:22

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Nerve plexuses are networks of interlacing nerves that serve as communication hubs to distribute and organize nerve action across various body regions. The nerve plexuses are organized into the cervical plexus located in the neck region, brachial plexus in the shoulder area, lumbar plexus found in the lower back, sacral plexus situated in the pelvis, and coccygeal plexus located in the coccygeal region.
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Reticular Dermis01:15

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Peripheral Nervous System: Ganglia and Nerves01:24

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The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
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An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
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Neurofibromatosis type 1: More than skin deep.

T Grant Phillips1, Osiris R Persia2, Jolenny A Jimenez Lopez3

  • 1UPMC Altoona Family Physicians Residency, PA, USA.

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|November 11, 2020
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Summary

This pediatric disease begins with skin manifestations and affects multiple organ systems as it progresses. Early diagnosis and management are crucial for patient outcomes.

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Area of Science:

  • Pediatric Dermatology
  • Systemic Diseases
  • Clinical Manifestations

Background:

  • Dermatologic findings are often the initial presentation of a progressive systemic disease in children.
  • The condition impacts multiple organ systems beyond the skin.
  • Understanding the progression is key for effective patient management.

Purpose of the Study:

  • To outline diagnostic and management strategies for a pediatric systemic disease.
  • To provide guidance for clinicians encountering this condition.
  • To emphasize the importance of early intervention.

Main Methods:

  • Review of clinical case studies.
  • Analysis of disease progression patterns.
  • Synthesis of current treatment guidelines.

Main Results:

  • Early dermatologic signs predict multi-organ involvement.
  • Timely intervention can alter disease trajectory.
  • Multidisciplinary care is essential.

Conclusions:

  • Prompt diagnosis of dermatologic findings is critical.
  • A systematic approach is necessary for managing multi-systemic progression.
  • Adherence to established protocols improves patient prognosis.