Constructing PCM with architecturally distinct higher-order assemblies
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Updated: Dec 1, 2025

Assembly and Characterization of Polyelectrolyte Complex Micelles
Published on: March 2, 2020
Kyung S Lee1, Jung-Eun Park1, Jong Il Ahn1
1Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Abstract:
Pericentriolar material (PCM) present around a pair of centrioles functions as a platform for various cellular processes, including microtubule (MT) assembly. While PCM is known to be an electron-dense proteinaceous matrix made of long coiled-coil proteins and their client molecules, the molecular mechanism underlying PCM organization remains largely elusive. A growing body of evidence suggests that PCM is constructed in part by an interphase cylindrical self-assembly and the mitotic mesh-like architectures surrounding it. In this review, we will discuss how these higher-order structures are constructed to achieve the functional proficiency of the centrosome.
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