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Updated: Dec 1, 2025
Three-Dimensional Reconstruction of Orbital Fractures
Published on: May 16, 2025
Acute Orbital Compromise after Intra-Arterial Chemotherapy in a Complex Retinoblastoma Associated with 13q Deletion
Sophia El Hamichi1, Dhariana Acon2, Veronica Kon Graversen3
1Murray Ocular Oncology and Retina, Miami, Florida, USA, sophiaelhamichi@gmail.com.
Introduction:
The intra-arterial chemotherapy (IAC) is increasingly used as a first-line therapy for retinoblastoma. The IAC has proved to be relatively safe. However, many local side effects of IAC have been described.
Case Presentation:
This case report describes a local side effect presenting as proptosis and myositis with vascular access difficulty of the middle meningeal artery, in a 2-year-old male with left eye diffuse multifocal stage Vb retinoblastoma complicated with retinal detachment.
Discussion/Conclusion:
IAC is assured to provide as efficient results in eliminating the tumor as the systemic chemotherapy, without causing the systemic side effects. It has become an alternative to systemic chemotherapy. A better understanding of the local side effects is required.
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