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Updated: Dec 1, 2025

The In ovo CAM-assay as a Xenograft Model for Sarcoma
Published on: July 17, 2013
Intracardiac extension of chondroblastic osteosarcoma
Mackenzie K Madison1, Caleb R Matthews1, Lawrence S Lee1
1Division of Cardiothoracic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Abstract:
Intravascular tumour extension invading the intracardiac space is rarely seen with osteosarcoma. We present a patient with a history of previously resected pelvic osteosarcoma who was later found to have a local recurrence with continuous intravascular extension from the right femoral vein to the right atrium. Preoperative imaging studies initially described extensive thrombus burden, and a multidisciplinary approach involving open and percutaneous thrombectomy was planned. Intraoperative inspection and pathological analysis revealed unresectable malignant solid tumour rather than thrombus. Though exceedingly rare, the possibility of metastatic tumour must be considered when planning treatment strategies for these patients.
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