Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

928
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
928
Seizures: Classification01:13

Seizures: Classification

1.1K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.1K
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

461
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
461
Antiepileptic Drugs: Sodium Channel Blockers01:08

Antiepileptic Drugs: Sodium Channel Blockers

1.3K
Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
1.3K
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

1000
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
1000
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

726
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
726

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stereo-EEG mapping of visual working memory with task-related high-gamma modulations.

Epilepsia·2026
Same author

Responsive Neurostimulation of Thalamic and Nonthalamic Targets in Pediatric and Young Adult Patients With Intractable Epilepsy.

Neurosurgery·2025
Same author

User-defined virtual sensors: A new solution to the problem of temporal plus epilepsy sources.

Epilepsia·2024
Same author

Role of optically pumped magnetometers in presurgical epilepsy evaluation: Commentary of the American Clinical Magnetoencephalography Society.

Epilepsia·2023
Same author

Comparing electrical stimulation functional mapping with subdural electrodes and stereoelectroencephalography.

Epilepsia·2023
Same author

Cross-Frequency Coupling in Childhood Absence Epilepsy.

Brain connectivity·2021

Related Experiment Video

Updated: Dec 1, 2025

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.1K

Epilepsy-Work-Up and Management in Children.

Jeffrey R Tenney1,2

  • 1Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Seminars in Neurology
|November 11, 2020
PubMed
Summary

Pediatric epilepsy diagnosis and treatment vary significantly with age. Understanding these age-related differences is crucial for accurate diagnosis, appropriate evaluations, and effective management in children with epilepsy.

More Related Videos

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

20.8K
Performing Behavioral Tasks in Subjects with Intracranial Electrodes
12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

11.6K

Related Experiment Videos

Last Updated: Dec 1, 2025

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.1K
Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
10:22

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy

Published on: December 6, 2016

20.8K
Performing Behavioral Tasks in Subjects with Intracranial Electrodes
12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

11.6K

Area of Science:

  • Neurology
  • Pediatrics
  • Epileptology

Background:

  • Pediatric epilepsy presents unique challenges due to age-related syndrome expression.
  • Children's epilepsy differs significantly from adult epilepsy, necessitating specialized approaches.
  • Accurate diagnosis and classification are vital for effective management and prognosis.

Purpose of the Study:

  • To provide a comprehensive review of the diagnosis, work-up, and management of pediatric epilepsy.
  • To highlight the age-related considerations in pediatric epilepsy.
  • To guide clinicians in establishing accurate diagnoses and treatment plans for children with epilepsy.

Main Methods:

  • Literature review focusing on pediatric epilepsy diagnosis, classification, etiology evaluation, and treatment.
  • Synthesis of current understanding of age-specific epilepsy syndromes in children.
  • Discussion of diagnostic and therapeutic guidelines tailored for pediatric populations.

Main Results:

  • Pediatric epilepsy is characterized by age-dependent syndromes requiring specific diagnostic and therapeutic strategies.
  • Age-related factors significantly influence epilepsy classification, etiological work-up, and treatment selection.
  • Tailored approaches improve seizure outcomes and family understanding of prognosis.

Conclusions:

  • Accurate diagnosis of pediatric epilepsy hinges on recognizing age-specific features.
  • Comprehensive evaluations and age-appropriate treatments are essential for optimal outcomes in children with epilepsy.
  • This review underscores the importance of specialized knowledge for managing pediatric epilepsy effectively.