Cu-Catalyzed Dehydrogenative Olefinsulfonation of Alkyl Arenes
Fangfang Li1, Guang'an Zhang1, Yingguo Liu2
1Green Catalysis Center, and College of Chemisty, Zhengzhou University, Zhengzhou 450001, P.R. China.
Abstract:
A copper-catalyzed reaction protocol for the dehydrogenation of ethylbenzenes into styrene derivatives has been developed. This reaction procedure proceeded well under mild reaction conditions, providing a practical and efficient strategy for the rapid assembly of biologically and pharmaceutically significant molecules, such as vinyl sulfone. Simple alkyl arenes were functionalized via consecutive β-elimination in the presence of N-sulfonylbenzo[d]imidazole with broad substrate scope and good functional group tolerance.
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