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Related Concept Videos

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RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Related Experiment Video

Updated: Nov 30, 2025

Identification of Circular RNAs using RNA Sequencing
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Research Progress on circRNA in Nervous System Diseases.

Nana Ma1, Wei Zhang1, Jun Wan1,2

  • 11Shenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University, The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, China

Current Alzheimer Research
|November 12, 2020
PubMed
Summary

Circular RNAs (circRNAs), stable non-coding RNA molecules, are crucial in nervous system diseases. Understanding circRNA dysregulation offers new avenues for diagnosing and treating conditions like Alzheimer's disease.

Keywords:
Alzheimer's diseaseCircular RNAParkinson diseasediseasenervous systemnon-coding RNA

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Area of Science:

  • Molecular Biology
  • Neuroscience
  • Genetics

Background:

  • Circular RNAs (circRNAs) are non-coding RNA molecules characterized by stable, covalently closed circular structures.
  • These molecules can be formed from exonic and/or intronic sequences.
  • Emerging research highlights the significant role of circRNAs in the development of neurological disorders.

Purpose of the Study:

  • To review the classification, characteristics, and biogenesis of circRNAs.
  • To summarize the association between circRNA dysregulation and nervous system diseases, including Alzheimer's disease.
  • To provide insights into novel research directions for the diagnosis, treatment, and prevention of these diseases.

Main Methods:

  • Literature review and synthesis of existing research on circRNAs and nervous system diseases.
  • Analysis of studies focusing on circRNA classification, biogenesis, and functional roles.
  • Examination of evidence linking circRNA dysregulation to specific neurological conditions.

Main Results:

  • CircRNAs exhibit diverse structures and biogenesis pathways.
  • Dysregulation of specific circRNAs is implicated in the pathogenesis of various nervous system diseases.
  • Alzheimer's disease is presented as a key example of a condition influenced by circRNA alterations.

Conclusions:

  • A comprehensive understanding of circRNAs is essential for advancing neuroscience.
  • CircRNA dysregulation represents a promising area for developing diagnostic and therapeutic strategies for neurological disorders.
  • Further research into circRNAs can lead to improved prevention and treatment approaches for nervous system diseases.