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Extensively drug-resistant Alcaligenes faecalis infection
1Department of Internal Medicine, Division of Chest Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, NO. 2, Min-Sheng Road. Dalin Town, Chiayi County, Taiwan. hgssport@yahoo.com.tw.
BMC Infectious Diseases
|November 12, 2020
Summary
Alcaligenes faecalis infections are challenging to treat due to rising antibiotic resistance. This study highlights emerging extensively drug-resistant strains and decreasing susceptibility to common antibiotics.
Area of Science:
- Clinical microbiology
- Infectious diseases
- Antimicrobial resistance
Background:
- Alcaligenes faecalis causes opportunistic infections in humans.
- Treatment is often difficult due to increasing antibiotic resistance.
- Clinical data can improve patient care for Alcaligenes faecalis infections.
Purpose of the Study:
- To analyze clinical data of patients with Alcaligenes faecalis infection.
- To identify common infection sites and comorbidities.
- To assess antibiotic susceptibility trends.
Main Methods:
- Retrospective analysis of 61 patients from January 2014 to December 2019.
- Review of medical records for demographics, symptoms, comorbidities, and antibiotic history.
- Analysis of bacterial cultures, antibiotic sensitivity tests, and clinical outcomes.
Main Results:
- Most frequent infection sites: bloodstream, urinary tract, skin/soft tissue, and middle ear.
- High prevalence of mixed bacterial infections (83.6%) and prior antibiotic use (60.7%).
- Decreasing susceptibility to common antibiotics; emergence of extensively drug-resistant strains since 2018.
Conclusions:
- Alcaligenes faecalis exhibits decreasing susceptibility to antibiotics.
- Extensively drug-resistant strains are emerging.
- Understanding resistance patterns is crucial for effective treatment.