A rare entity of Primary Ewing sarcoma in kidney

Area of Science:

• Oncology
• Pathology

Background:

• Ewing sarcoma (ES) or primitive neuroectodermal tumors (PNET) are aggressive malignancies.
• Renal Ewing sarcoma (RES) is a rare kidney cancer, comprising less than 1% of renal masses.
• RES often presents with uncharacteristic symptoms, leading to diagnosis via postoperative pathology.

Observation:

• A case of RES presented with intermittent left flank pain and a palpable abdominal mass.
• The aggressive nature of this renal malignancy was observed.
• Therapeutic modalities and outcomes for RES were summarized.

Findings:

• Diagnosis of RES relies on histomorphology, immunohistochemical staining, and molecular-genetic testing.
• Surgery and adjuvant therapy were administered.
• The case highlighted the aggressive behavior and diagnostic challenges of RES.

Implications:

• Optimized and potent therapeutic regimens are urgently needed to improve the poor prognosis of RES.
• Integrated diagnostic approaches are crucial for accurate RES identification.
• Further research into novel therapeutic strategies is warranted for this rare renal malignancy.