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Updated: Nov 30, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Pain is a common problem in patients with ILD.

Qinxue Shen^1,2,3, Ting Guo^1,2,3, Min Song^1,2,3

¹Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital of Central-South University, NO.139 Renmin Middle Road, Changsha, 410011, Hunan, China.

Respiratory Research

|November 12, 2020

Summary

Pain is common in interstitial lung disease (ILD) patients, affecting over 60%. Pain intensity correlates with exposure history, walking distance, and dyspnea severity, often leading to reduced quality of life and psychological distress.

Keywords:

Brief pain inventory (BPI)Healthy controls (HC)Hospital anxiety and depression scale (HADS)Interstitial lung disease (ILD)Modified medical research council dyspnea scale (mMRC)Short form McGill pain questionnaire (SF-MPQ)Short form-36 (SF-36)Six minutes walking test (6MWT)

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Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex

Published on: July 4, 2018

Area of Science:

Pulmonology
Pain Medicine
Quality of Life Research

Background:

Prevalence and characteristics of pain in interstitial lung disease (ILD) are not well-understood.
This study investigates pain in ILD patients.

Purpose of the Study:

To determine the prevalence and characteristics of pain in patients with ILD.
To explore associations between pain and clinical factors, quality of life, and psychological status in ILD patients.

Main Methods:

63 ILD patients and 63 healthy controls (HC) completed pain questionnaires (SF-MPQ, BPI-SF).
ILD patients underwent Pulmonary Function Tests, 6-Minute Walking Test (6MWT), and mMRC dyspnea assessment.
Health-related quality of life (HRQoL) and psychological status (HADS) were measured.

Main Results:

Pain prevalence was 61.9% in ILD vs. 25.3% in HC (P=0.005).
Chest pain was most common (46.1%) in ILD patients.
Pain intensity correlated with ILD risk factor exposure, longer 6MWD (≥250m), and higher mMRC scores (2-4).
ILD patients with pain showed impaired HRQoL and higher rates of anxiety and depression.

Conclusions:

Pain is prevalent in ILD patients and linked to exposure history, 6MWD, and mMRC score.
ILD patients experiencing pain are at higher risk for depression, anxiety, and diminished HRQoL.