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[Ultrastructural changes in plague microbes, strain EV, and splenic cells of guinea pigs in their interaction in
Abstract:
Dilatation of the endoplasmic reticulum cavities, an increase in the number of ribosomes near bacteria, deformation of mitochondria and coarsening of cristae were revealed in phagocytosis of Past. pestis, strain EV, by reticular cells in the tissue culture of the spleen of intact guinea pigs. Lipophanerous "reticular" inclusions were found in the differentiated reticular cells of the infected cultures. In the reticular cell cytoplasma besides the intact bacteria there were revealed Past. pestis at the initial stages of involution.
Insights
Phagocytosis of Yersinia pestis by guinea pig spleen reticular cells causes cellular damage and bacterial involution. These findings offer insights into the host-pathogen interactions during plague pathogenesis.
Area of Science:
- Cell Biology
- Microbiology
- Immunology
Background:
- Reticular cells play a crucial role in the immune response.
- Yersinia pestis is a bacterium that causes plague.
- Understanding host-pathogen interactions is vital for disease control.