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Dysgonic fermenter 2 septicemia.

H Hicklin1, A Verghese, S Alvarez

  • 1Department of Medicine, Veterans Administration Medical Center, Johnson City, Tennessee 37684.

Reviews of Infectious Diseases
|September 1, 1987
PubMed
Summary
This summary is machine-generated.

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Dysgonic fermenter 2 (DF-2) causes zoonotic infections, primarily through dog contact. High-risk patients, like those splenectomized or with liver disease, face severe septicemia, necessitating prompt diagnosis and penicillin prophylaxis.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Zoonoses

Background:

  • Dysgonic fermenter 2 (DF-2) is a gram-negative bacillus.
  • It causes zoonotic infections transmitted via dog bites or contact.
  • Certain patient groups, including splenectomized individuals and those with alcoholic liver disease, are highly susceptible.

Observation:

  • DF-2 infection can manifest as fulminant septicemia and disseminated intravascular coagulation in splenectomized patients.
  • In patients with alcoholic liver disease, the presentation is typically milder.
  • The reported mortality rate for DF-2 septicemia is 27%.

Findings:

  • The organism is sensitive to penicillin but resistant to aminoglycosides.
  • DF-2 is difficult to culture on standard media and appears sensitive to normal human serum.

Related Experiment Videos

  • Penicillin prophylaxis for dog bite wounds is crucial for high-risk individuals.

    • Implications:

    • DF-2 infection should be suspected in splenectomized patients presenting with severe sepsis, DIC, and gangrene.
    • Gram staining of peripheral blood or buffy coat can aid in diagnosis.
    • Early recognition and appropriate antibiotic therapy, particularly penicillin, are vital for improving outcomes.